Symptomatic relief of OA, RA & ankylosing spondylitis.
Dosage/Direction for Use
OA 200 mg once daily or in 2 divided doses, may be increased to 200 mg bd. RA 200 mg in 2 divided doses, may be increased to 200 mg bd. Ankylosing spondylitis 200 mg once daily or in 2 divided doses, may be increased to 400 mg once daily or in 2 divided doses. Max recommended daily dose for all indications: 400 mg. Elderly >65 yr 200 mg once daily, may be increased to 200 mg bd if needed.
Administration
May be taken with or without food: For patients w/ swallowing difficulties, contents may be added to applesauce/rice gruel/yogurt/mashed banana.
Contraindications
Hypersensitivity to celecoxib & sulphonamides. Active peptic ulceration or GI bleeding. Inflammatory bowel disease; CHF (NYHA II-IV); established ischaemic heart disease, peripheral arterial disease &/or cerebrovascular disease. Patients w/ severe heart failure. Patients w/ estimated CrCl <30 mL/min. Patients who have allergic type reactions after taking aspirin or other NSAIDs (including COX-2 inhibitors). For the treatment of peri-op pain in the setting of CABG surgery. Women of childbearing potential. Pregnancy & lactation.
Special Precautions
Skin & systemic hypersensitivity reactions. GI risks (eg, bleeding, ulceration, perforation of stomach or intestines). Avoid concomitant use w/ a non-aspirin NSAID. CV, hepatic & renal effects. Closely monitor BP. Use w/ caution in patients at risk for fluid retention & oedema. Known poor CYP2C9 metabolisers. May mask fever & other signs of inflammation. Patients on concurrent therapy w/ warfarin. Rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption. May impair ability to drive & use machines.
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